You are trapped in a room with a monster. As if that wasn't bad enough, there are gunmen outside the room shooting at you when the portals open. To advance, you must shoot the gunmen when the portals are open. You can also shoot the monster but it will only be stunned and if you stay in the same room too long, the monster becomes immune to your weapon.
There are sixty-four different ways this game can play out. In some versions, the gunmen fire straight at you from one direction, while others aim at wherever you are. Some are slow, while others are fast, and some all open their portals at the same time and stay that way. Each version offers a unique challenge.
Room of Doom is scored as follows: shooting a gunman earns 75 points each, and stunning the monster gives you 50 points per stun.