The Sega Dreamcast version of Atelier Marie & Elie is a role-playing game that follows the story of two young alchemists, Marie and Elie, as they live in the town of Salburg. The game takes place several years after the events of the first Atelier game, where the sisters were still alive and living together. Now, they are on their own, working to perfect their alchemy skills and uncover the secrets of their village.
Gameplay involves exploring a large open world, completing quests, and engaging in turn-based battles with enemies. The player must manage Marie and Elie's relationships, as well as their respective skills and equipment. Alchemy is a key part of the game, allowing players to craft new items and potions using various ingredients.