Missile Command is set in a world where cities are under threat from an alien invasion. The story follows your role as the commander of the defence force, tasked with protecting these urban centres from enemy missile attacks.
The gameplay involves navigating a 3D grid to defend against incoming missiles, using various weapons and power-ups to take out the enemy. Counter-strike capabilities allow you to launch retaliatory attacks on enemy positions. The game also features multiplayer functionality, allowing you to compete with other players in Ultimate mode, which offers enhanced graphics and locations.