Destruction begins when Destroy All Humans: Path of the Furon , a Psychic Powers driven alien named Furon, crash-lands on Earth. He soon discovers that he is an outcast from his planet and decides to wreak havoc on humanity.
The gameplay revolves around Furon's mission to destroy every human on Earth using his psychic powers, gadgets and high-tech vehicles. As players progress through the game, they must evade government agents and other foes while carrying out their evil plans.