The story of El Shaddai: Ascension of the Metatron takes place in a fantastical interpretation of biblical themes, inspired by the apocryphal Book of Enoch. Enoch is sent by God to capture the angels that have fallen into their duties to watch over the human world. These angels, called Grigori, became fascinated with their charges and renounced Heaven to live and breed among humans. Enoch must traverse their realms, battle their aberrant Nephilim offspring, finally locating the fallen angels and bringing them back into Heaven's fold. As Enoch journeys, he is assisted by the head archangel Lucifel.
El Shaddai: Ascension of the Metatron is a third-person action game that emphasizes platforming and melee combat. The combat system uses few buttons, relying on button timing to effect light, heavy, and counterattacks. Enoch has no weapons of his own and must rely on stealing enemies' weapons via counterattacks. These weapons degrade and must be periodically purified or discarded for new ones. Combat occurs in arena-like encounters, which then give way to either 3D exploration or 2D platforming. The game's art style is primarily watercolor, with each angel's realm having a distinct theme.
El Shaddai: Ascension of the Metatron was released on September 9th, 2011, exclusively for the Playstation 3 console. It falls under the genres of Action & Adventure.