You take on the role of Hellboy, the demon from hell who was raised by humans. The story centers around a plot by Hellboy: The Science of Evil , an insane Nazi who has hatched a plan to take over the world with the help of his personal army, the kriegaffen.
The single player features six levels, during which you must take out multiple enemies in brawler-style combat, using Hellboy's signature "Right Hand of Doom", building up combos that will allow you to unleash special moves onto enemies. You can also use Hellboy's Samaritan pistol, which fires single, powerful bullets.
As you play through the game, you'll encounter puzzles and obstacles that require creative problem-solving using unique Samaritan ammo types or other items. Collectibles throughout the game will shed light on the story and improve Hellboy's energy storage capacity.
The game also features a co-op mode for playing over Xbox Live or PSN, where one player controls Hellboy and another player takes on the role of Abe Sapien or Liz Sherman. Additionally, there is a PSP version of Hellboy: The Science of Evil available.