Warhammer 40.000: Space Marine is a third-person shooter set in the Warhammer 40.000 universe, where the player takes on the role of Captain Titus, a member of the Ultra Marines, an elite section of the Space Marines.
The mission is to drive back the Orc invasion on the industry planet Graia and protect a super weapon that could fall into the wrong hands. Along the way, Titus must also contend with Chaos Marines and other alien races.
Gameplay involves walking through levels with fellow Marines, killing enemy hordes. The focus lies in melee combat, with a range of weapons at Titus' disposal. Combo attacks can be performed by using the correct buttons with timing, and powerful attacks can be unleashed when enough fury is earned by killing enemies.
Titus also participates in rail shooter sequences and occasionally receives a jet pack, along with more open level design. The game's focus on melee combat means there is no cover system, instead relying on regenerative shields and health that can be regained through executions.