Darksiders III is an action role-playing game where the player returns to a post-apocalyptic Earth as Fury, one of the Four Horsemen of the Apocalypse, on a quest to hunt down and dispose of the Seven Deadly Sins. From a behind view, she fights enemies using her whip and Hollow weapons acquired throughout the game.
The combat is no longer combo-focused with varied ground and aerial moves, rooms full of enemies, and a hit counter. Instead, it is slower, grounded, and methodical, focusing on Fury's dodge and counters. Combat scenarios are not "gated" anymore, so the player can choose between eliminating enemies spread throughout the map or simply passing them.
The leveling system and buffs are now a central part of the gameplay. Enemies drop Souls when they are killed, as in the first game, but now the Souls are dropped every time the player dies. They then take the form of a glowing blue sphere which can be recovered by hitting it, and are placed somewhere near the point of their last death. Souls are used as a form of currency, but are also an integral part of the leveling system.
Weapons can be given perks by equipping them with Runes. These can be upgraded upon talking to Ulthane and providing him with the proper materials that can be collected by exploring different areas in the game.
The game's difficulty is scaled every time Fury defeats one of the Sins, and all enemies in the game are buffed to match her level.