Ghostbusters follows the further adventures of Peter, Ray and Egon as they try to piece together a mysterious stone tablet. The story takes place after the events of the first movie, with the Ghostbusters facing off against various ghosts in different locations.
The gameplay involves side-scrolling platforming, where the players control the Ghostbusters as they battle ghosts using their proton blasters. They can trap bosses and collect power-ups to upgrade their abilities and equipment. The game features shops throughout the levels where the players can purchase upgrades.