Joe & Mac 3 follows the adventures of Joe and Mac, two cavemen ninjas, as they attempt to rescue a group of girls from their evil captor. The girls have been kidnapped by a rival tribe, and it's up to Joe and Mac to navigate through treacherous terrain, avoiding deadly traps and battling fierce enemies.
The gameplay involves jumping, clubbing, and throwing various objects at enemies, using items such as boomerangs, bones, fire, flints, electricity, and stone wheels. Players must use their wits and skills to overcome obstacles and defeat their foes in a bid to rescue the kidnapped girls and save the day.