Grim Adventures of Billy & Mandy is based on the Cartoon Network series of the same name. The game plays very much like an arena fighter, similar to Power Stone .
The story begins when Grim's Mojo Balls are unleashed into Endsville, causing all residents to gain supernatural rage and leading to mass fighting and mayhem. It is up to Grim, Billy, Mandy, and Irwin to figure out who unleashed the balls.
Each character has special abilities, moves, and weapons to use. They also have a Mojo meter, which is a power bar that fills up as they fight. Once filled, it can be used to deal heavy damage or knock out all players.
The game features several levels that are destructible, with most major characters from Grim Adventures of Billy & Mandy and various single-player and multiplayer modes.