The Incredible Hulk Ultimate Destruction follows the story of the Incredible Hulk as he seeks to destroy New York City. After being exposed to gamma radiation, which alters his physical form and mental state, the Hulk becomes driven by a desire for revenge against humanity.
Players take control of the Hulk as he wreaks havoc on the city, smashing through buildings and fighting against various enemies. The gameplay is fast-paced and action-packed, with an emphasis on destruction and mayhem.