A unique twist on the music game genre, Rock Band 3 Fender Squier Stratocaster Guitar allows players to take on the role of a rock star. The game's story follows the player's character as they attempt to save their band from being dissolved due to lack of funds.
Gameplay involves playing along with popular songs, performing vocals and guitar parts to create a full-band experience. Players can also switch between different instruments, such as drums or bass, to add depth to their performance. The game features a wide range of songs, including rock, pop, and punk classics, all of which are performed using the in-game controllers.