Players control Spider-Man as he navigates through the streets of Manhattan, fighting against a range of enemies including Electro, Rhino, and Kraven. The gameplay is centered around web-slinging, parkour, and combat, with an emphasis on exploration and puzzle-solving.
The game features a variety of playable characters, including Spider-Man's friends and allies, such as Mary Jane Watson and Harry Osborn. Each character has their own unique abilities and moveset, which can be upgraded and customized throughout the game.