The game follows the story of Newt, an android who finds himself on a prison transport ship, the USM Auriga. After being attacked by a group of deadly creatures, Newt must navigate through the ship's corridors, fighting off hordes of deadly Xenomorphs and other alien species.
Gameplay involves controlling Newt as he navigates through levels, using his wits and whatever tools are available to him to take down enemies. The game features a variety of power-ups and upgrades that can be used to aid Newt in his quest to survive.