The Ghostbusters game is based on the 1984 film of the same name, where the team must capture ghosts using their proton packs and traps. However, New York City has become a hotspot for paranormal activity, and the Ghostbusters' task is to reduce the city's ghost power before an evil goddess called Gozer awakens.
Ghostbusters is an action game that features an overhead-view and a side-view. From Ghostbusters HQ, the player must monitor a map of midtown Manhattan for "ghost alarms", as well as for casual spirits, and plot a route to the alarmed area. Once the route is plotted, the player controls the purchased Ghostmobile as it drives through traffic, capturing ghosts on the way if they are en route. When the haunted location is reached, the game switches to a side-view, where two Ghostbusters must lead a ghost over a trap to capture it.
As the game progresses, the PK energy in the city increases. The Ghostbusters team must keep it under critical levels by being constantly successful at busting ghosts. Eventually, the Temple of Zuul will activate, and if the PK levels are manageable, the Ghostbusters can venture there for a final showdown with Gozer.