Duke Nukem Advance follows Duke Nukem as he travels around the world to stop alien scientists from taking over Earth. The aliens have already occupied Area 51 and it's up to Duke to stop them and save the day.
The game features 19 stages, each with its own secrets and colored keycards. Players will also encounter various alien nasties and classic villains like Pig Cop. Duke can use his shrink ray and freezer to take down enemies.
Up to four GameBoy Advance consoles can be linked together for a multiplayer deathmatch mode, but each player needs their own GamePack.