A young boy named David lives on Earth with his older brother. One day, a spaceship appears above their home and drops off an alien boy, who has been transported to Earth from his own planet. The alien's name is Stitch, but he quickly gets into trouble by causing chaos in the neighborhood.
David takes it upon himself to care for Stitch, but things get complicated when other aliens arrive looking for him. As David tries to navigate his new responsibilities as a guardian, he must also deal with the consequences of Stitch's antics.
The gameplay follows the relationship between David and Stitch as they try to evade capture by the alien hunters. Players control both characters, switching between them to solve puzzles, avoid obstacles, and fight off enemies. The game features a variety of action-packed sequences, including chases and combat, as well as more relaxed exploration sections.
Disney's Stitch Experiment 626 was released on the Playstation 2 console in November 2000 for Europe and North America.