Destroy All Humans! is a humorous action game with winks to the era of the goofy fifties' sci-fi movies. I, Cryptosporidium 137 of the Furon Empire, happened upon your planet on the way back from destroying the martians. Due to some experiments with atomic weaponry, we lack genitalia and the quality of our clones has degraded. Since you pathetic humans all carry Furon DNA in your genetic code, I have been instructed to collect fresh samples. Survival is not an option, but you should be honoured to support the legacy of the Furon Empire!
Destroy All Humans! lets you control Crypto as he explores a 3D open world, completing missions and causing chaos. You can hypnotize and scan people, lift objects using psychokinesis, and even control humans using the Hypno Blast to impose your commands. Extracted DNA can be exchanged in your mothership for new weapons and ability upgrades. Furon weaponry includes a Zap-o-Matic, disintegrator ray, abducto beam, quantum deconstructor, and even the famous anal probe. There are different alert levels, similar to the Grand Theft Auto games, and if you're not careful, you'll be hunted down by the police, military, or government.
You are constantly in contact with your mothership, where you can purchase upgrades, save the game, and apply for new missions. Crypto doesn't have to run all the time; he can also use his flying saucer to abduct humans or animals, cause havoc, or face bigger threats. Next to the story-based missions, you'll also be instructed to collect specific samples or kill a certain amount of humans in a race against time.