You play as Hellboy, a demon from hell raised by humans. The story revolves around Hermann Von Klempt's plot to take over the world with his Nazi army, the kriegaffen. You must stop him and save humanity.
The gameplay is a mix of brawler-style combat, puzzle-solving, and collecting items. You'll use Hellboy's "Right Hand of Doom" moves, throw objects at enemies, and fire powerful bullets from the Samaritan pistol. You can also solve puzzles using special ammo types to progress through levels.
Hellboy: The Science of Evil features six single-player levels and a co-op mode for two players over Xbox Live or PSN. Players take on roles as Hellboy, Abe Sapien, or Liz Sherman. Additionally, there's a PSP version available.
Hellboy: The Science of Evil was released on August 29th, 2008 for the Xbox 360 console.