Fifteen years after the events of Ridley Scott's Alien Ellen Ripley's daughter Amanda is looking for answers. She is an engineer working for Weiland-Yutani Corporation. When she finds out that the logs from USCSS Nostromo have been located and transported to Sevastopol space station she decides to join a small crew sent by Weiland-Yutani to retrieve the data. Little does she know that the ship that has found the logs reached Sevastopol with a terrifying passenger on board, the one that murdered the majority of station's population and left the survivors cowering in fear.
Alien: Isolation is a survival horror game set on the Sevastopol space station where Amanda is searching for USCSS Nostromo logs. The player has a certain degree of freedom to explore the station, with multiple routes to goals, hidden rooms, and ventilation shafts. As the game progresses, Amanda's tools will be upgraded, allowing her to access previously out-of-reach areas.
Amanda is an engineer, so she can loot containers and bodies for resources and craft devices like noisemakers, smoke bombs, or Molotov cocktails, mainly used to distract the enemy. Later, she acquires a flashlight, a motion detector, and several types of weapons to defend herself against humanoid enemies, such as hostile survivors or androids. However, Amanda is not a fighter, and each encounter should be carefully planned.
When Amanda draws attention from the alien, stealth is the only way to survive. The alien cannot be harmed, and it kills Amanda in a single hit. In most cases, it doesn't follow a predetermined scripted route but relies on its senses to track her down.
In addition to the main story mode, there's Survivor mode, where the player needs to escape from a specially designed map while fulfilling secondary objectives along the way, being aggressively hunted by the alien. This mode includes online leaderboards.