The gameplay involves controlling one of several teams, each with its own unique abilities and strengths, as they compete in high-energy football matches against their opponents. The twist is that these are not your ordinary football matches - players can use special moves, such as flying kicks and spinning tackles, to gain an advantage over their opponents.
Mutant Football League Dynasty Edition features a season mode where you can manage your team, make tactical decisions, and compete against other teams in the league. The game also includes a career mode where you can create and customize your own player, as well as a versus mode for single-player matches.