The story begins with Edward 'Stubbs' Stubblefield, a traveling salesman who dies in the 1930s. Years later, in 1959, wealthy businessman Andrew Monday builds his dream city, Punchbowl Pennsylvania, on top of Stubbs' grave. You play as Stubbs, who must fight through all of Punchbowl's citizens to reach Monday.
Stubbs has an army of zombie helpers and learns special body powers. He can use his flatulence to stun enemies, throw his pancreas as a grenade, detach his head to attack from above, and even send his hand out to scout ahead and take control of enemy humans.