Standing in the turtles' way are various enemies, including Foot Clan bots, Mouser droids, and Kraang soldiers. Players can switch between the four turtles at any time, each using their signature weapons and having a slightly different fighting style and moves. Basic moves include simple attacks and blocks, while landing a hit combo and pressing attack again sends the turtle's weapon spinning, allowing players to launch a "Shell Kicker" - an extra powerful move that can knock away an enemy's shield, knock them back, deal extra damage, or get the turtle behind the enemy.
Defeating enemies gains experience points, which allow upgrading of the Shell Kicker attacks. If a turtle is defeated, he is captured by the enemy and can be rescued by rescuing him from where he is held. New abilities are earned by finding power-ups or meeting with allies like April or Casey in story sequences, including double jumps and dashes, as well as the ability to throw various kinds of shuriken or smoke bombs.
There are several boss battles against the likes of Rahzar, Baxter Stockman, and the Shredder. The voice actors from the TV series reprise their roles for the game.
