Generator Rex: Agent of Providence , based on the kids' show on Cartoon Network, is a beat-em-up action game where players control Rex as he battles against the E.V.O.'s and nanite problems threatening the Earth. The story follows Rex's quest to stop villain Van Kleiss from causing harm.
The gameplay revolves around Rex's journey to collect evidence against Van Kleiss while trying to regain his lost powers. Players must navigate through levels, fighting enemies and absorbing nanites in infected people who have turned into monsters. Rex's powers include the Smackhands, Slam Cannon, BFS, and Funchucks, which can be re-earned throughout the game.
Gameplay typically features beat-em-up sections, but there are brief breaks with driving stages that require shooting skills, followed by a falling sequence where players must dodge enemies and debris. When in the Providence headquarters, players can replay completed stages in time trial challenges to test their skills.