The evil mad scientist Dr. Frankenbeans has created a time machine to destroy the Looney Tunes world by erasing their ancestors with an army of robots. The player takes control of Bugs Bunny, Daffy Duck, Tazmanian Devil, Foghorn Leghorn, Marvin the Martian and Gossamer to stop him.
The gameplay is similar to 3-D platformers, with jumping, punching, shooting, but with the added use of the Wii remote and Nunchuk. Each character has unique abilities, such as Foghorn Leghorn's fists or Taz's deadly belch, while a weapon vending machine offers a variety of items.
The health system is the same, but players can switch between characters if one dies. The game features multiplayer options, with similar gameplay to the single-player mode, and an exclusive level on the PlayStation 2 version.