The gameplay in Retro City Rampage DX is fast-paced and intense, with players able to choose from a variety of characters each with their own unique abilities. The game features a mix of platforming, shooting, and melee combat, requiring players to use strategy and quick reflexes to overcome obstacles and enemies. With its challenging levels and varied gameplay mechanics, Retro City Rampage DX offers a thrilling experience for fans of action-adventure games.