Captain Rhama Sabrier is invited by the old healer Areliano to investigate a mysterious ship below the island. Rhama finds out that the ship was used to transport rare healing herbs and contains clues for finding them and bringing them to the healer. But at this point, everything goes wrong. Rhama and Areliano are betrayed, and soon the Captain finds himself on the run. He doesn't abandon the quest, though. Aided by Faith, Areliano's lovely daughter, and other friends he meets on his journey, Rhama is determined to bring the betrayer to justice and deliver the ship's legacy to the right hands.
Further stand-out features include cooperation between characters (similarly to ICO , though Rhama has two female companions), a treasure hunt system (Rhama can use his pirate senses to discover hidden treasures), and boss battles that require climbing on the enemies to destroy them, in a style similar to Shadow of the Colossus .