Axiom Verge is a 2D metroidvania platform shooter centered around the protagonist Trace, a scientist who, after an experiment gone wrong, finds himself on the world of Sudra. By the time Trace arrives on Sudra he finds this world and his civilization collapsed due to the release of the "Pathogen". With help of the Russalki (giant war machines that guard Sudra), Trace has to fight back the invading forces and return back across The Breach to Earth.
The game features an open world where Trace can travel freely, but needs better gear and weapons to progress. Players can find items to unlock new paths, including a Modified Labcoat, Grapple, Laser Drill, Address Disruptor, and Remote Drone. Some weapons can be used to access secret areas. Upgrades for health and weapons can also be found while exploring the game's world.
The environment on Sudra varies greatly from area to area, with different alien flora and fauna present in each region. Enemies respawn after leaving a general area, but leave behind some health when killed.