The story of The Ren and Stimpy Show Buckeroos follows the adventures of Ren, a rough-around-the-edges outlaw, and his trusty sidekick Stimpy, a dim-witted but lovable buddy. The duo embarks on a quest to find the legendary Golden Acorn, while being pursued by the villainous Sheriff Harley. Along the way, they encounter various obstacles, including treacherous terrain, ferocious beasts, and their own ineptitude.
The gameplay of The Ren and Stimpy Show Buckeroos is a side-scrolling action-adventure experience that challenges players to navigate through levels filled with danger. Ren can run, jump, and shoot his way through hordes of enemies, while Stimpy provides a unique perspective as he crawls along the ground, gathering power-ups and items. The game's difficulty level increases as players progress through the levels, requiring them to think strategically and use their abilities wisely.