Escape The Museum is a hidden object game with elements of the adventure genre. Besides the usual gameplay mechanic of finding objects from a list by clicking on them, the game has adventure portions where the player must collect and use objects to escape from a room. These sections follow simplified puzzle patterns.
The player's goal is to search previous levels for specific objects and collect 12 precious artifacts throughout the game. The game keeps track of accuracy, time, object value, and hint usage to calculate a score.
Additional gameplay features include mini-games such as reassembling paintings like jigsaw puzzles and balancing scales by shifting weights until they reach equilibrium.