The story takes place after an unspecified event, where Superman kills General Zod. The DC Universe is in chaos, and various heroes and villains must come together to form the Justice League to take down their enemies.
The gameplay consists of a hand-to-hand fighting system with 2D gameplay elements and characters that can use some weapons, such as the Batmobile. Some scenarios are inspired by DC comics, like the Fortress of Solitude (Superman), the Batcave (Batman), and the Watchtower (Justice League). There are 28 playable characters available in this game, including 12 heroes, 12 villains, and 4 downloadable ones.