Rampage World Tour, an updated version of the classic Rampage , follows three lab technicians who have mutated after exposure to toxic waste at Scumlabs International. George has become a gigantic ape, Lizzy a gigantic lizard or dinosaur, and Ralph some sort of gigantic wolf. The three wreak havoc on the world, destroying buildings, eating civilians, and battling militaries.
The player chooses one of these characters and embarks on a path of destruction. Their goal is to rid the world of Scumlabs by traveling to cities where they are located. However, this requires destroying numerous cities along the way. Scumlabs and their militaries are determined to stop them and may even team up with another player in a two-player mode.
The game features colorful, cartoon-like graphics and varied gameplay. Players can climb buildings, punch, kick, and eat inhabitants to destroy them. Once all buildings for a stage are destroyed, the stage is cleared, and players proceed to the next one. Power-ups are available, granting increased power or restoring health.