Scooby Doo 2: Monsters Unleashed begins by taking place at a museum where the gang is donating masks and costumes of every crook they have caught. The story follows their journey as they move through various levels, completing objectives along the way.
The gameplay in Scooby Doo 2: Monsters Unleashed involves navigating through side-scrolling platform levels, using abilities such as jumping, attacking, climbing, and more to overcome obstacles. Be careful not to let your courage meter drop too low, or you'll be forced to restart from the beginning. A dropped courage meter acts similarly to a life meter in other games.