Ta-Keed, the Prince of Darkness, has escaped from his supernatural prison and is seeking revenge on those who locked him away. Emperor Hans sends troops to deal with Ta-Keed, but they are no match for him. The emperor summons four adventurers who possess magical bells to defeat Ta-Keed. These four characters must work together to reach the castle and destroy Ta-Keed.
The game Little Samson begins with each character's journey from their homeland to the emperor's palace. This allows the player to explore each character's unique abilities, which will be essential throughout the game.
The four characters have different skills: Samson is a human who excels at climbing and can shoot bells straight ahead. Kikira is the Dragon Lord, with claws that prevent slipping on ice and the ability to fly short distances while jumping. Gamm is the Rock Lord, an indestructible rock-like creature with incredible strength and a powerful punch. K.O. is the Mouse Lord, small and fast, allowing him to enter areas others cannot and drop time-delay bombs.
When all four characters reach the emperor's palace, they must jump into Samson's bell. Initially, Kikira refuses, but eventually joins the group after a brief fight with Ta-Keed. Throughout the game, the player can switch between any of the four characters by entering the sub-screen.
The characters share lives, and if one loses all their power, one life is lost for the team. The player must switch between the four characters to complete the journey and destroy Ta-Keed.