Yuri Minami is a young teacher working at Seitei Gakuen, a campus containing all levels of school until university. Yuri is still new to the middle school when she receives a surprising promotion to the high school. However, the reasons behind her move become clear when she finds that she is assigned as homeroom teacher to the infamous Class X. A particular group of students known as the B6 (Baka 6) give the class its bad reputation: Tsubasa Makase, the spoiled son of an English model and a Japanese businessman, is fluent in English but struggles with Japanese; Hajime Kusanagi, a former soccer player known for his volatile temper and bad memory; Goro Fuumonji, a short boy who dresses as a girl and values art, at the expense of hating math; Shun Nanase, the bass player of a rock band who would rather spend his time working and making money than going to school; Mizuki Madarame, a quiet and remarkably lazy student who spends most of his time sleeping; and Kiyoharu Sendou, an excellent basketball player who finds joy in tormenting his superiors with pranks. The majority of the B6 have been held back, or are facing expulsion. It is now up to Yuri to turn around their academic performance and lead them to graduation.
Vitamin X is an otome visual novel in which the player, as Yuri, must choose a student and improve their academics while pursuing a relationship. Each character has two endings, which are determined based on how many Love or Study points the player has accumulated over the course of the school year. Throughout each route, the boys have lines that are inaccurate or completely false. When the player spots such a line, they have two options: letting it slide earns the player Love points, while correcting the mistake earns Study points. A certain number of both Love points and Study points must be collected in order to achieve the "Perfect" end, in which the student typically graduates high school to go on to the college of their dreams and begins a relationship with Yuri.
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