Cradle of Rome 2 is the sequel to Cradle of Rome. Just like its predecessor, it is a puzzle game played on a board filled with different items. The objective is to remove all items on blue tiles on the board. This is done by creating a match of three tiles or more with an identical item, horizontally or vertically.
The main Adventure mode consists of 100 levels through 5 epochs with increasing difficulty and new tiles appearing further in game. During the game, the player earns resources that can be used in-between levels to turn a small village into an empire. Blueprints for new buildings are earned through a matching pairs mini-game. The game's visuals consist of hand-painted graphics.