The gameplay is an action & adventure mix, allowing for exploration, interaction with objects, and application of inventory items. The game features cinematic sequences and quick-time events during action scenes, as well as stealth mechanics where the player must avoid detection by zombies. Conversation options also have a significant impact on the storyline, with multiple choices that can alter the outcome.
The game's setting is in the original universe of the comic book series, but does not rely on characters or locations from the TV series. Instead, it tells a parallel story through Lee Everett, who becomes entangled with Clementine and other characters as he navigates a hostile environment filled with zombies.