The player takes on the role of Clementine, who initially travels with Omid and Christa but soon finds herself alone and must make tough decisions to survive. The gameplay is largely unchanged compared to the predecessor, with an emphasis on making choices that affect the story's outcome.
The game features a mix of action sequences, puzzles, and mini-games, with a focus on quick-time events and interactive dialogue choices. Clementine's answers have consequences that can impact the game's progression, adding depth to the narrative. The player must navigate these challenges within time limits, making for an intense and immersive experience.