Battletoads follows the story of Zitz, Rash, and Pimple - three toads with unique fighting abilities - who get caught up in a confrontation with the Dark Queen on the Lost Vega leisure space station. The game begins with Rash and Pimple being kidnapped by the Dark Queen, prompting Zitz, the main playable character, to chase after her while navigating through treacherous obstacles.
As you control Zitz, you'll experience various gameplay styles, including walking, flying, and racing. You'll need to beat up enemies that get in your way, avoid taking damage from hostile aliens, or shoot down enemies in mid-air. Each level culminates in a boss battle against formidable foes.