The story of Danganronpa V3: Killing Harmony follows a group of students who are trapped in Hope's Peak Academy. The academy is a prestigious school that accepts only the best students, but it has a dark secret. The students soon discover that they have been forced to participate in a deadly game where one student will be killed off each day. To survive, the students must gather clues and solve puzzles to uncover the truth behind their confinement.
Gameplay involves navigating through the academy's corridors, attending classes, and participating in investigation sessions with the other students. The player takes on the role of a student trying to uncover the truth and escape the academy alive. The game features multiple endings depending on the choices made throughout the story. The gameplay is fast-paced, with an emphasis on puzzle-solving and strategy.