The Mission mode consists of four boards that culminate with a boss card battle at the end. During the board game portion, players can earn items and will be forced to participate in mini-game events. If the player defeats all of the boards, they will be given an opportunity to play a fifth board and will get a chance to have a battle with the UNO King.
The gameplay involves strategic card play, as well as navigating through different environments on the four boards. The game requires players to make quick decisions and use their skills to overcome obstacles and defeat opponents.