Sinistron is a side-scrolling shooter similar to R-Type, but has a unique weapons system in which you can open and close your shields to improve your fire power at the expense of making your ship vulnerable. There are also several different power-ups you can pick up such as missiles and different types of lasers.
The plot in the game is not very clear according to the instruction booklet. Apparently, a "Sinistron" has invaded your quadrant of the galaxy and you have to blow it up, just for the sake of it.
The gameplay involves navigating through levels with large enemy sprites and large boss characters. The levels take place mostly in outer space and alien environments. Some of the sprites are Macross-like mechs.
The Japanese version, "Violent Soldier", had slightly different graphics compared to the TurboGrafx-16 release.
Sinistron was released on the TurboGrafx-16 in 1991 and is a game that can be enjoyed by fans of action-packed shooters.