The boxers' skills are defined by three parameters: power, speed, and defense. They develop following from how well the player does in some training minigames. The game modes include Arcade, Quick Fight (versus the CPU or another player), Championship, Team Fight, Tournament, Create a Boxer (items are unlocked gradually by reaching achievements), and Mini Game (to develop one's boxer's skills). A tutorial and a register of records are also available.
Boxers in Ready 2 Rumble Revolution are imitations of renowned people from the show in facial features, while their names are suggestive of their origin or related to their body shape. Secret fighters can be unlocked by completing the Championship Mode.