The main game mode, Supremacy Stories, features a narrative that follows each character. Some characters are modeled after real-world athletes, including Jens Pulver, Jerome Le Banner, Malaipet and β as one of two female fighters β Felice Herrig. Supremacy MMA marks the introduction of female fighters to a MMA video game.
The game offers classic VS battles, online modes, and Supremacy Stories mode for each character. Additionally, there are two Tournaments modes: Battle Royale and Survival Ladder.