The Muppets On With the Show brings back Jim Henson's beloved Muppets to the Game Boy Advance. In this game, aimed at kids, the player has to help the Muppets create a new Muppet show and complete six activity games where the player controls one of the muppets and performs various tasks.
The gameplay varies for each activity, involving different types such as racing, fighting, music-making, and evasion. Each activity has an explanation screen that clearly explains what needs to be done, and after completing the activity, the player's score is displayed with a rating out of five stars (maximum). The game can be played in either Story mode (easy, medium, or hard) or Activity mode, where players can freely play certain activities.