The New Adventures of Mary-Kate & Ashley game follows the adventures of Mary-Kate and Ashley as they navigate through different environments. The story revolves around their dog Clue, who is trapped in cages and needs to be rescued by the player. Along the way, the sisters use their unique abilities to overcome obstacles and reach the puzzle pieces that will unlock the cages.
The gameplay involves flipping switches, grabbing puzzle pieces, and using the characters' special abilities to navigate through levels. Each character has a distinct ability: Mary-Kate can jump higher, Ashley can flip switches, and Clue can be used as a platform or thrown at enemies. The player must switch between the three characters to progress through the game. With 50 levels across five cases, players will need to use their skills and strategy to overcome the challenges ahead.