The New Adventures of Mary-Kate & Ashley game is about three friends, Mary-Kate, Ashley, and their dog Clue, who go on adventures together. Their goal is to flip a switch to open a cage, grab the puzzle piece inside before it closes, and then find their way through levels filled with enemies and hazards.
The gameplay involves switching between the three characters, using each one's special abilities to overcome obstacles. Mary-Kate can jump higher, while Ashley can pick up and throw Clue to help them progress. The game has 50 levels spread across five cases, and players can collect clues scattered throughout the level to help them if they get stuck.