Big Nose's American Adventure takes place on a cross-country road trip across the United States. Players control Big Nose, an eccentric explorer who must navigate through various obstacles and challenges to reach his destination.
The gameplay involves controlling Big Nose as he drives through different environments, collecting items and avoiding enemies. The twist is that Big Nose's long nose can be used as a tool, such as reaching high platforms or breaking certain objects. As the player progresses, new abilities and upgrades become available.