Accord, teacher of the local magic school, has lost her magic flying cane. There is word of an award so the students are busy searching high and low for it. Naturally, our heroes Amitie and her school nemesis Raffine make their way toward the distant dark castle, challenging - and being challenged by - everyone you come across in a game of Puyo Pop Fever .
Puyo Pop Fever is a puzzle game of the falling-block variety, where your goal is to clear blocks (Puyos) by combining four or more of the same color. When this happens, they disappear and produce Nuisance Puyos. These colorless Puyos will fall onto your opponent's screen, blocking their chances of creating chains and combos. You can only get rid of these pesky Puyos by clearing neighboring ones.
When an opponent sends Nuisance Puyos to your screen, you can try to offset by clearing your own Puyos and limiting the number that would fall on your screen. This will also fill up your Fever Meter, which increases when you clear Puyos. When this meter is full, you'll be given a set of prearranged Puyos to create giant combos and send Nuisance Puyos back to your opponent. The game ends when any player's field becomes too full to drop more Puyos.
The game features a two-player mode, where you can compete against each other in a battle of wits. Some versions allow for more players, such as the Gamecube version, which supports up to eight players in free-for-all or team modes.